Spinning bioreactor enables efficient and scalable organoid culture

Amsbio has introduced the RPMotion, a spinning organoid bioreactor designed to streamline and scale up organoid culture for applications in drug discovery, disease modelling and regenerative medicine.

Organoid expansion has traditionally been a slow and resource-intensive process, often relying on static culture methods that demand large volumes of reagents, significant hands-on time and skilled manual handling. The RPMotion system is designed to address these limitations by automating key aspects of organoid growth and differentiation in small-scale formats.

Operating in 5–50 ml volumes, the bioreactor enables continuous dynamic culture conditions that support more rapid organoid development. According to Amsbio, the system can deliver up to five times faster organoid expansion compared with conventional methods, while also reducing culture reagent use by around 60% and labour requirements by approximately 75%.

The unit is designed for minimal intervention, with cultures maintained within standard incubators and monitored without the need to repeatedly open the system. An external LCD control interface allows users to select and adjust programmed workflows depending on organoid type and experimental requirements.

For higher-throughput workflows, the RPMotion can run up to four tubes simultaneously, enabling parallel experiments within a single unit. Multiple devices can also be linked via a plug-and-play configuration, allowing up to 28 additional bioreactors to be controlled through one interface.

Alongside improved productivity, the system is intended to support more consistent organoid quality, making it suitable for applications where reproducibility is critical, including GMP-aligned workflows.

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