Litesizer DLS: Earlier tracking of thermogelation

Analysers

Litesizer DLS: Earlier tracking of thermogelation

08 Jun, 2026

Thermoresponsive polymers such as methylcellulose are widely used in pharmaceutical, biomedical, food, and personal-care applications because they reversibly form gels when heated. Yet accurately identifying the onset and progression of gelation remains difficult, as conventional bulk methods often detect the transition only after a stable macroscopic network has formed.

Litesizer DLS enables earlier and more detailed insight into thermally induced gelation by simultaneously monitoring diffusion coefficient, scattered-light intensity, and transmittance during temperature-dependent measurements. 

By combining multiple parameters in a single measurement, Litesizer DLS supports faster formulation screening, deeper understanding of thermoresponsive behaviour, and improved process optimisation. 

Complementary techniques: Litesizer DIA and Litesizer DIF

Complementary particle characterisation techniques can provide even broader insight: Litesizer DIA enables detailed analysis of powder morphology and particle size distribution before dissolution, while Litesizer DIF extends characterisation capabilities for complex dispersions and particle systems.

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